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Prochlorperazine

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Prochlorperazine Description
Prochlorperazine is a medication for nausea that's sometimes used to help with morning sickness, even though it's not officially approved for that purpose.
It works by blocking dopamine receptors in your brain, which helps to reduce nausea signals and ease the symptoms.
Typically taken three times a day, with at least two hours between each dose. It starts working within 30 to 60 minutes.

What is Prochlorperazine?

Prochlorperazine is a tablet that helps with various conditions causing nausea and dizziness. It's also sometimes used for morning sickness, or nausea and vomiting during pregnancy, even though it's not officially approved for this use.

You've likely heard of morning sickness, but feeling nauseous and vomiting during pregnancy can actually happen at any time of the day. It's quite normal in the early stages of pregnancy. However, if it's very severe, lasts throughout your pregnancy, or stops you from eating and drinking enough, it's important to get some help.

Prochlorperazine works by blocking the signals in your brain that cause nausea and vomiting, helping you to eat and live normally once more. This way, you can concentrate on enjoying a happy and healthy pregnancy.

How does Prochlorperazine work?

Prochlorperazine is a medication known as a phenothiazine. It helps prevent nausea and vomiting by targeting D2 receptors in the brain. By reducing the activity of dopamine, which can lead to nausea, it effectively eases these symptoms.

Dopamine is a hormone that plays a role in controlling the chemoreceptor trigger zone (CTZ), also known as the vomiting centre, in the brain. Having an excess of dopamine can activate this centre, leading to nausea and vomiting. Prochlorperazine works by blocking the D2 receptors, effectively tackling the cause of the sickness.

What doses of Prochlorperazine are there?

Prochlorperazine is available in 5mg tablets. For nausea and vomiting during pregnancy, the typical dose is usually between 5mg and 10mg. Your clinician will determine the best dose for you. They might suggest starting with a lower dose and increasing it if your nausea isn't managed effectively.

During pregnancy, you typically take Prochlorperazine up to three times a day. Make sure to space out your doses by at least two hours. It's important to use the smallest effective dose for the shortest duration to minimise any potential effects on the baby.

How long does it take Prochlorperazine to work?

Prochlorperazine typically begins to work within 30 to 60 minutes after you take it, so you should feel some relief from your nausea fairly quickly. It generally takes about a week for the medication to reach stable levels in your body.

If you've been taking Prochlorperazine for several days and haven't noticed any improvement in your nausea, it's important to see your clinician. If your nausea worsens or you show signs of severe dehydration, seek medical help immediately.

What should I do if I make an error while taking Prochlorperazine?

If you accidentally take too much Prochlorperazine, seek medical help immediately. Bring the medication packaging with you so they can check what you've taken and the amount. You might feel dizzy or sleepy. Avoid driving if you feel drowsy; consider taking a taxi or asking someone to drive you.

If you miss taking your Prochlorperazine at the usual time, simply skip that dose and take the next one as scheduled. Avoid taking two doses to compensate for the missed one. Be careful not to handle the tablets for too long, as they might cause redness and irritation on your skin. Also, Prochlorperazine can increase your sensitivity to the sun, so it's important to use suncream and cover up when you're in direct sunlight.

How is Prochlorperazine different from other treatments for morning sickness?

There are a few other tablets available for nausea and vomiting during pregnancy. The only one officially approved for use in pregnancy is Xonvea tablets, which have been available since 2018. Xonvea combines the antihistamine doxylamine with vitamin B6, both of which are known to help with pregnancy-related nausea and vomiting.

Cyclizine is another option; it's an antihistamine commonly used for morning sickness. Unlike Prochlorperazine, Cyclizine targets histamine receptors instead of dopamine receptors, but both help with sickness. Metoclopramide, like Prochlorperazine, acts on the D2 receptors in the brain. However, they are different types of medication with distinct active ingredients, so their effects on you might vary slightly.

How effective is Prochlorperazine?

Prochlorperazine is effective for morning sickness. It's a strong remedy for nausea, and it works similarly during pregnancy. In a study involving 174 women in their first trimester, there was a notable reduction in vomiting when they used Prochlorperazine.

Here are a few self-care tips for managing morning sickness that can enhance the effectiveness of Prochlorperazine. Consider having several small meals throughout the day rather than a few large ones. Drinking peppermint tea or using ginger in any form can help calm your stomach and reduce nausea.

Do I need a prescription for Prochlorperazine?

Prochlorperazine can only be obtained with a prescription. It's considered an off-label treatment for morning sickness, so a healthcare professional will need to ensure it's safe for you. If you discuss your health with us, we can assist you in finding the appropriate treatment for morning sickness.

If Prochlorperazine tablets are the right option for you, one of our clinicians can approve your prescription and arrange for your medication to be delivered directly to your home.

Important Information

Prochlorperazine isn't right for everyone, and there are a few things you should know before taking it.

Here's all the official information about it. If anything isn't clear, please let our clinician know, and they can discuss it with you.

Always Read The Patient Information Leaflet

Medicines can cause side effects. Always read the leaflet that comes with your medication and report any side effects to your pharmacist. Stay informed—order safely today!

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