Skin Boosters & Polynucleotides
Revive dull, dehydrated skin from within. Our injectable skin treatments deliver deep hydration, stimulate collagen, and restore a luminous, healthy glow — no filler, no volume, just radiance.
Hydrate, Regenerate and Glow — From the Inside Out
Skin boosters and polynucleotides represent the next generation of injectable skin treatments. Rather than adding volume or sculpting contours like dermal fillers, these treatments work beneath the surface to improve your skin's quality at a cellular level — boosting hydration, stimulating collagen and elastin production, and accelerating tissue repair.
The result is skin that looks healthier, feels firmer, and carries a natural luminosity that no topical product can replicate. These treatments are suitable for the face, neck, under eyes, and hands — and work beautifully as standalone rejuvenation or as a complement to other aesthetic procedures.
Skin Boosters
Injectable hyaluronic acid treatments that flood the deeper layers of the skin with hydration, improving texture, elasticity, and overall radiance without adding volume or changing facial shape.
How They Work
Skin boosters use ultra-pure, free-flowing hyaluronic acid that spreads evenly beneath the skin rather than sitting in one place like a filler. The HA attracts and binds water molecules, creating a reservoir of moisture that hydrates from within. Over time, this stimulates your skin's own collagen and elastin production, improving firmness and reducing fine lines.
Best For
- Dull, dehydrated, or tired-looking skin
- Fine lines and crepey texture on the face and neck
- Smokers, sun-damaged skin, or mature skin losing elasticity
- Pre-event skin prep for a natural, lit-from-within glow
- Hands showing visible signs of ageing
Products We Use
Profhilo, Seventy Hyal, and Mesotherapy cocktails — each selected based on your skin's needs and your practitioner's clinical assessment.
Polynucleotides
Bio-stimulating injectables derived from purified DNA fragments (polynucleotide chains) that trigger deep tissue regeneration, improve skin quality, and support healing at a cellular level.
How They Work
Polynucleotides activate fibroblasts — the cells responsible for producing collagen, elastin, and hyaluronic acid within your own skin. Unlike skin boosters that deliver hydration directly, polynucleotides signal your body to regenerate tissue from scratch. This makes them particularly effective for areas with thin, damaged, or ageing skin where structural repair is needed.
Best For
- Under-eye hollows, dark circles, and crepey under-eye skin
- Skin that has lost firmness or structural integrity
- Acne scarring and post-inflammatory damage
- Overall skin quality improvement and anti-ageing
- Complementing other treatments (fillers, peels, microneedling)
Products We Use
Lumi Eyes (under-eye specialist), Nucleofill (under eye and full face), and Plinest — premium polynucleotide products chosen for their purity, efficacy, and proven clinical results.
Available Skin Booster & Polynucleotide Treatments
Each treatment is selected for its clinical evidence, product quality, and the results we see in our own patients.
Profhilo
One of the highest concentrations of hyaluronic acid on the market. Profhilo spreads across five bio-aesthetic points on each side of the face, flooding the tissue with deep hydration and triggering collagen and elastin remodelling. A two-session course spaced four weeks apart delivers optimal results.
Seventy Hyal
A next-generation skin booster that delivers targeted hydration and bio-stimulation for improved skin texture, tone, and elasticity. Particularly effective for fine lines and loss of radiance. Treatment plan tailored during your consultation.
Mesotherapy
Micro-injections of a customised cocktail of vitamins, minerals, amino acids, and hyaluronic acid delivered directly into the mesodermal layer of the skin. Targets specific concerns including dullness, dehydration, pigmentation, and fine lines.
Lumi Eyes
A polynucleotide-based treatment designed specifically for the delicate under-eye area. Targets dark circles, fine lines, and crepey skin around the eyes by stimulating deep tissue regeneration where topical products cannot reach.
Nucleofill
A premium bio-stimulator available for both the under-eye area and the full face. Nucleofill activates fibroblasts to rebuild collagen and elastin, delivering visible improvement in skin firmness, texture, and luminosity over a course of treatments.
Plinest
A highly purified polynucleotide gel that promotes cellular renewal and tissue repair. Plinest is used to address overall skin ageing, loss of radiance, and structural weakness in the skin — delivering progressive improvement with each session.
Benefits of Skin Boosters & Polynucleotides
Deep Hydration
Moisture delivered beneath the surface where topical creams cannot reach
Natural Glow
A lit-from-within radiance that looks effortless, not manufactured
Collagen Stimulation
Your skin builds its own collagen and elastin for lasting firmness
No Downtime
Walk in at lunch, walk out glowing. Return to your day immediately
Under-Eye Specialist
Polynucleotides target dark circles and hollows that filler cannot safely treat
Pairs Beautifully
Combine with fillers, peels, or microneedling for elevated results
Suitable for Most
Gentle treatments suitable for a wide range of skin types and ages
Progressive Results
Each session builds on the last — skin improves over the course
Skin Boosters vs Polynucleotides
Both improve skin quality, but they work differently. This comparison helps you understand which approach — or combination — may suit you best.
| Skin Boosters | Polynucleotides | |
|---|---|---|
| Primary action | Delivers deep hydration via hyaluronic acid | Stimulates cellular regeneration via DNA fragments |
| Key benefit | Intense moisture, improved texture and glow | Tissue repair, collagen rebuilding, firming |
| Best areas | Face, neck, hands | Under eyes, face, areas with thin or damaged skin |
| Results appear | 1–2 weeks (hydration), 4–6 weeks (full glow) | 4–6 weeks (progressive with each session) |
| Sessions needed | Typically 2, spaced 4 weeks apart | Typically 2–3, spaced 3–4 weeks apart |
| Downtime | None — small wheals resolve in hours | None — mild redness for 24–48 hours |
| Can combine? | Yes — pairs with fillers, peels, microneedling | Yes — enhances results of other treatments |
What to Expect at Your Appointment
Skin Assessment
Your practitioner evaluates your skin quality, hydration levels, and concerns to recommend the most effective treatment and product for you.
Cleanse & Prep
The treatment area is thoroughly cleansed. Topical numbing cream is applied if needed, though most patients find these treatments very comfortable.
Micro-Injections
Small, precise doses are injected across the treatment zone using ultra-fine needles. The procedure takes 20–30 minutes depending on the area covered.
Aftercare & Course Plan
You receive written aftercare instructions and your practitioner books your next session. Most treatments work best as a short course for optimal, lasting results.
Common Side Effects
Skin boosters and polynucleotides carry a very low risk profile. Normal post-treatment responses include:
- Small raised bumps (wheals) at injection points — flatten within 2–6 hours
- Mild redness and swelling for 24–48 hours
- Tenderness and slight bruising at injection sites
- Mild itching as the product distributes beneath the skin
Serious complications are rare. If you notice increasing redness, heat, pain, or discharge beyond 48 hours, contact the clinic promptly.
View full complications guidance →Key Aftercare
Follow these essentials for the first 24 hours after your skin booster or polynucleotide treatment:
- Leave skin product-free for 6 hours — no make-up, SPF, or serums
- Do not touch or rub the treated area
- Avoid exercise, swimming, saunas, and heavy sweating
- Skip alcohol for 24 hours
- Use only a gentle, fragrance-free cleanser when you first wash
- Stay well hydrated — water amplifies the results of HA treatments
Skin Boosters & Polynucleotides FAQ
What is the difference between skin boosters and dermal fillers?
Skin boosters improve your skin's quality — hydration, texture, firmness, and glow — without adding volume or changing facial shape. Dermal fillers add volume to sculpt contours, restore lost fullness, and smooth deep lines. Think of skin boosters as treating the skin itself, and fillers as reshaping the structures beneath it. The two work beautifully together.
Do skin booster injections hurt?
Most patients find these treatments very comfortable. The needles used are ultra-fine, and a topical numbing cream can be applied beforehand. You may feel a mild pricking sensation during the injections, but it is typically well tolerated.
How many sessions will I need?
Most skin boosters (including Profhilo) work best as a course of two sessions spaced four weeks apart. Polynucleotide treatments typically require two to three sessions spaced three to four weeks apart. Your practitioner will recommend a personalised plan during your consultation. Maintenance sessions every four to six months help sustain results.
When will I see results?
You may notice improved hydration and a subtle glow within one to two weeks of your first session. The full effect — including firmer, more luminous skin — develops over four to six weeks as collagen remodelling takes place. Results continue to build with each subsequent session.
Can I have skin boosters around my eyes?
Yes. Polynucleotide treatments such as Lumi Eyes and Nucleofill Under Eye are specifically designed for the delicate periorbital area. They target dark circles, fine lines, and crepey texture that is difficult to treat with other methods. Your practitioner will assess whether you are a suitable candidate during your consultation.
Are these treatments suitable for all skin types?
Skin boosters and polynucleotides are suitable for a wide range of skin types and tones. They are particularly beneficial for patients with dehydrated, sun-damaged, or mature skin. A consultation is essential to determine which product and protocol is right for your individual needs and to rule out any contraindications.
What are the small bumps I can see after treatment?
Small raised bumps (wheals) at the injection points are completely normal and expected. They are caused by the product sitting just beneath the skin surface. These typically flatten within two to six hours and are not visible the next day.
Can I combine skin boosters with other treatments?
Absolutely. Skin boosters and polynucleotides pair exceptionally well with dermal fillers, anti-wrinkle injections, chemical peels, and microneedling. Many patients use skin boosters as a foundation treatment to improve overall skin quality, then layer targeted treatments on top. Your practitioner can design a combined plan tailored to your goals.
Is there any downtime?
There is no downtime with skin booster or polynucleotide treatments. You can return to your normal routine immediately. Mild redness and small bumps at injection sites are temporary and typically resolve within hours. We recommend avoiding make-up for 6 hours and strenuous exercise for 24 hours.
How long do results last?
After completing a full course, results typically last four to six months. Maintenance sessions every four to six months help sustain the improvements. Because these treatments stimulate your own collagen production, some patients find that skin quality continues to improve between maintenance sessions.
Ready for Healthier, Glowing Skin?
Book your consultation and discover which skin booster or polynucleotide treatment is right for you — tailored to your skin, your goals, and your lifestyle.